The emerging studies surrounding the nitrate debate in this Research Topic, and beyond, are charting the health impact of dietary nitrate and nitrite altering our attitude toward these compounds. However, both the health benefits and potential negative effects point to more sustainable and healthy eating practices: i.e., consuming more vegetables and fewer processed meats. While the nitrate debate is yet to be solved, it is reasonably clear that the food matrix, particularly the co-existing compounds in the wholefood, should be considered.
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Zhong, L., Liu, A. H., Blekkenhorst, L. C., et al. (2022). Development of a food composition database for assessing nitrate and nitrite intake from animal-based foods. Molecular nutrition & food research, 66(1), e2100272. Article ↗
Zhong, L., Blekkenhorst, L. C., Bondonno, N. P., et al. (2022). A food composition database for assessing nitrate intake from plant-based foods. Food chemistry, 394, 133411. Article ↗
Erichsen, D. W., Pokharel, P., Kyrø, C., et al. (2024). Source-specific nitrate and nitrite intakes and associations with sociodemographic factors in the Danish Diet, Cancer and Health cohort. Frontiers in Nutrition, 11, 1326991. Article ↗
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Erichsen, D. W., Kyrø, C., Schullehner, J., et al. (2026). Source-specific nitrate and nitrite intake and bladder cancer: findings from the Danish Diet, Cancer and Health Cohort. Environment International, 214, 110387. Article ↗
Alhulaefi, S. S., Watson, A., Brandt, K., et al. (2026). Exploring the associations between dietary nitrate and nitrite intake and markers of self-reported periodontal disease in the UK Biobank cohort. European Journal of Nutrition, 65(5), 174. Article ↗
Mazahery, H., Black, L. J., Daly, A., et al. (2025). Higher dietary nitrate intake is associated with lower likelihood of first clinical diagnosis of central nervous system demyelination in Australian women. Multiple Sclerosis and Related Disorders, 96, 106376. Article ↗
Erichsen, D. W., Kyrø, C., Pokharel, P., et al. (2026). Source-specific nitrate and nitrite intake and associations with gastric cancer in the Danish Diet, Cancer and Health Cohort. European Journal of Epidemiology, article in press. Article ↗
English, C. J., Bondonno, C. P., Zhong, L., et al. (2026). Association of source-specific nitrate intake with inflammation and cardiometabolic health: A cross-sectional study. British Journal of Nutrition, article in press. Article ↗
Bondonno, N. P., Pokharel, P., Parmenter, B. H., et al. (2026). Associations between source-specific nitrate and nitrite intakes and metabolic dysfunction-associated steatotic liver disease in two prospective cohorts. Clinical Nutrition, 60, 106628. Article ↗
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Pokharel, P., Blekkenhorst, L., Bondonno, C., et al. (2025). Associations of vegetable and potato intakes with markers of type 2 diabetes risk in the AusDiab Cohort. The Journal of Clinical Endocrinology and Metabolism, 110(4), e1068–e1083. Article ↗
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Blekkenhorst, L. C., Bondonno, N. P., Liu, A. H., et al. (2021). Vegetable but not potato nitrate intake is associated with a lower risk of cardiovascular disease mortality in older adult women. European Journal of Nutrition, 60, 3279–3292. Article ↗
Sim, M., Blekkenhorst, L. C., Bondonno, N. P., et al. (2021). Dietary nitrate intake is positively associated with muscle function in men and women independent of physical activity levels. The Journal of Nutrition, 151(5), 1222–1230. Article ↗
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Fejes, R., Séneca, J., Pjevac, P., et al. (2025). Increased nitrate intake from beetroot juice over 4 weeks changes the composition of the oral, but not the intestinal microbiome. Molecular Nutrition & Food Research, 69(20), e70156. Article ↗
Fejes, R., Lutnik, M., Weisshaar, S., et al. (2024). Increased nitrate intake from beetroot juice over 4 weeks affects nitrate metabolism, but not vascular function or blood pressure in older adults with hypertension. Food & Function, 15(8), 4065–4078. Article ↗
Zhong, L., Mills, C., Fluitman, K. S., et al. (2026). Effect of dietary nitrate intake on urinary N-nitrosamines: A randomized controlled clinical trial with crossover design. The American Journal of Clinical Nutrition, article in press. Article ↗
Raubenheimer, K., Zhong, L., Bondonno, N. P., et al. (2024). Effects of nitrate-rich beetroot juice on markers of vascular function, inflammation and oxidative stress in postmenopausal women with above-normal blood pressure. Food & Function, 15(7), 3562–3570. Article ↗
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Du, P., Bondonno, N. P., Murray, K., et al. (2024). Effects of cruciferous compared with root and squash vegetables on blood pressure in adults with mildly elevated blood pressure: A randomized crossover trial. BMC Medicine, 22, 446. Article ↗
Bondonno, C. P., Yang, X., Croft, K. D., et al. (2012). Nitrate causes a dose-dependent augmentation of nitric oxide status in healthy women. Food & Function, 3(7), 668–673. Article ↗
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Bondonno, C. P., Blekkenhorst, L. C., Lewis, J. R., et al. (2024). Editorial: Dietary nitrate – friend or foe? Frontiers in Nutrition, 11, 1424859. Article ↗
Bondonno, C. P., Zhong, L., & Hodgson, J. M. (2026). Reply to Wu et al.: “Nitrate and nitrite food composition database: an update and extensive deep dive”. The American Journal of Clinical Nutrition, 124(1), 101358. Letter. Article ↗
Zhong, L., Hodgson, J. M., Lewis, J. R., Blekkenhorst, L. C., Bondonno, N. P., Sim, M., Woodman, R. J., & Bondonno, C. P. (2025). Nitrate and nitrite food composition database: An update and extensive deep dive. The American Journal of Clinical Nutrition, 121(5), 1124-1136. https://doi.org/10.1016/j.ajcnut.2025.01.031